Tramadol, Codeine, and Risk of Adverse Outcomes.

The article discusses a study on the adverse outcomes of tramadol or codeine among residents of Catalonia, Spain, which references a research paper published within the issue. Topics discussed include the use of propensity score matching in the study, the incidence of all-cause mortality and cardiovascular events following tramadol and codeine prescriptions, and the difference in the patterns of codeine prescribing in the U.S. from Europe.