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Adrenal androgen trajectories are established during childhood in preterm boys.
- Source :
-
Acta Paediatrica . Nov2021, Vol. 110 Issue 11, p3116-3123. 8p. - Publication Year :
- 2021
-
Abstract
- <bold>Aim: </bold>We investigated longitudinal adrenal androgen concentrations and any relationship between gestational age, birth size, anthropometric parameters and adrenal androgen concentrations during childhood in boys born moderate to late preterm.<bold>Methods: </bold>This longitudinal, prospective study included 58 boys born at 32+0 to 36+6 weeks of gestation. Dehydroepiandrosterone sulphate and androstenedione were analysed by liquid chromatography-tandem mass spectrometry, and anthropometric data were recorded from 5 to 10 years of age.<bold>Results: </bold>Dehydroepiandrosterone sulphate concentrations correlated with weight standard deviations scores (SDS) from 7 to 10 years of age and waist-to-height ratios at seven and 10 years of age. Androstenedione correlated with weight SDS from 7 to 10 years of age and waist-to-height ratios at 10 years of age. Longitudinal analysis showed a relationship between weight SDS and waist-to-height SDS and dehydroepiandrosterone sulphate (p < 0.001 and p < 0.001, respectively) and androstenedione (p = 0.002 and p = 0.003, respectively), independently of age.<bold>Conclusion: </bold>The trajectories of anthropometric parameters and adrenal androgen secretion were consistent from 5 to 10 years of age in this cohort. The body composition reflected by current weight and the waist-to-height ratio, rather than gestational age and birth size, was associated with adrenal androgen secretion. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08035253
- Volume :
- 110
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Acta Paediatrica
- Publication Type :
- Academic Journal
- Accession number :
- 153156278
- Full Text :
- https://doi.org/10.1111/apa.16036