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Efficacy of 1 g Ceftriaxone Monotherapy Compared to Dual Therapy With Azithromycin or Doxycycline for Treating Extragenital Gonorrhea Among Men Who Have Sex With Men.
- Source :
-
Clinical Infectious Diseases . 10/15/2021, Vol. 73 Issue 8, p1452-1458. 7p. - Publication Year :
- 2021
-
Abstract
- Background Evidence on efficacy of high-dose ceftriaxone monotherapy for extragenital Neisseria gonorrhoeae (NG) infection is lacking. Methods A cohort of men who have sex with men (MSM) were tested for NG/ Chlamydia trachomatis (CT) every 3 months, in a single-center observational study in Tokyo, Japan. MSM aged > 19 years diagnosed with extragenital NG infection between 2017 and 2020 were included. A single dose of 1 g ceftriaxone monotherapy was provided, while dual therapy with a single oral dose of 1 g azithromycin or 100 mg doxycycline administered orally twice daily for 7 days were given, for those coinfected with CT, according to infected sites. Efficacy of these treatments was calculated by the number of NG-negative subjects at test-of-cure divided by the number of subjects treated. Fisher exact tests were used to compare the efficacy between the 2 groups. Results Of 320 cases diagnosed with extragenital NG, 208 were treated with monotherapy and 112 were treated with dual therapy. The efficacy against total, pharyngeal, and rectal infections was 98.1% (204/208, 95% confidence interval [CI]: 95.2–99.3%), 97.8% (135/138, 95% CI: 93.8–99.4%), and 98.6% (69/70, 95% CI: 92.3–99.9%), respectively, in the monotherapy group, whereas the corresponding efficacy in the dual therapy was 95.5% (107/112, 95% CI: 90.0–98.1%), 96.1% (49/51, 95% CI: 86.8–99.3%), and 95.1% (58/61, 95% CI: 86.5–98.7%), respectively. No significant difference in the corresponding efficacy was observed between the two groups (P = .29, P = .61, P = .34, respectively). Conclusions High-dose ceftriaxone monotherapy is as effective as dual therapy for extragenital NG among MSM. [ABSTRACT FROM AUTHOR]
- Subjects :
- *EPIDEMIOLOGY of sexually transmitted diseases
*DRUG efficacy
*CEFTRIAXONE
*GONORRHEA
*SCIENTIFIC observation
*PHARYNGEAL diseases
*CONFIDENCE
*CONFIDENCE intervals
*CLINICAL trials
*TIME
*ORAL drug administration
*RECTAL diseases
*DOXYCYCLINE
*FISHER exact test
*COMPARATIVE studies
*MEN who have sex with men
*AZITHROMYCIN
*CHLAMYDIA trachomatis
*DATA analysis software
*LONGITUDINAL method
Subjects
Details
- Language :
- English
- ISSN :
- 10584838
- Volume :
- 73
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Clinical Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 153129146
- Full Text :
- https://doi.org/10.1093/cid/ciab455