脂肪干细胞来源外泌体在组织再生修复中的作用及热点分析.

BACKGROUND: Adipose-derived stem cells have become one of the popular seed cells in regenerative medicine due to abundant content and easy harvest. Adipose-derived stem cell exosomes are served as a bridge and link among adipose-derived stem cells and other cells and have the effects on regulating immune and inflammatory responses, promoting self-repair of damaged cells, and are considered as an alternative treatment for adipose-derived stem cells. OBJECTIVE: To review research progress and challenges in the adipose-derived stem cell exosomes regulating tissue regeneration. METHODS: CNKI, Wanfang database and PubMed, and Web of Science database were searched for related articles with the search terms of “adipose-derived stem cells; adipose stem cells; exosomes” in English and Chinese. After preliminary screening of articles based on inclusion and exclusion criteria, 70 articles with high relevance and reference value were retained for review. RESULTS AND CONCLUSION: Adipose-derived stem cell exosomes have shown the therapeutic potential in various diseases, such as skin wounds, neurodegenerative diseases, tumors, bone regeneration, kidney diseases, cardiovascular diseases, immune diseases, and fibrotic disease. [ABSTRACT FROM AUTHOR]