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Guanine Quadruplexes in Cell Nucleus Metabolism.

Authors :
Marilovtseva, E. V.
Studitsky, V. M.
Source :
Molecular Biology. Sep2021, Vol. 55 Issue 5, p705-726. 22p.
Publication Year :
2021

Abstract

Cell metabolism depends, to a large extent, on correct regulation of gene expression. One of the mechanisms of regulation is the formation of nucleic acid secondary structures, among which guanine quadruplexes (G-quadruplexes, or G4) are of particular importance. G-quadruplexes are dynamic structures whose stability is determined by their size, ionic composition, and the nature of the nucleic acids forming them. They are regulated by various protein factors. Guanine quadruplexes play an important role in the regulation of many processes occurring in DNA and RNA, from maintaining telomere homeostasis to determining the ribosome landing site on mRNA. Therefore, these structures are considered a promising target for antitumor therapy, and their detailed study is important to modern biology. This review is focused on the structure and thermodynamic properties of G-quadruplexes together with their interaction with some nuclear proteins. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00268933
Volume :
55
Issue :
5
Database :
Academic Search Index
Journal :
Molecular Biology
Publication Type :
Academic Journal
Accession number :
153099115
Full Text :
https://doi.org/10.1134/S0026893321040075