Clozapine treatment in a wider context: From before eligibility to life beyond clozapine.

This can sometimes be done by augmentation too, by using a clozapine sparing antipsychotic drug that facilitate clozapine dose reduction. Clozapine remains the golden standard for patients with treatment-resistant schizophrenia. As years go by on clozapine, many patients have the desire to reduce the dose or discontinue clozapine, and some patients may manage their disease with reduced dose of clozapine or without clozapine. Paradoxically, later in the course the patient may have developed less vulnerability to adverse effects and may then tolerate the sufficient dose needed in the clozapine eligibility criteria. [Extracted from the article]