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Design and Validation of a Surface-Contact Electrode for Gastric Pacing and Concurrent Slow-Wave Mapping.
- Source :
-
IEEE Transactions on Biomedical Engineering . Aug2021, Vol. 68 Issue 8, p2574-2581. 8p. - Publication Year :
- 2021
-
Abstract
- Objective: Gastric contractions are, in part, coordinated by slow-waves. Functional motility disorders are correlated with abnormal slow-wave patterns. Gastric pacing has been attempted in a limited number of studies to correct gastric dysmotility. Integrated electrode arrays capable of pacing and recording slow-wave responses are required. Methods: New flexible surface-contact pacing electrodes (SPE) that can be placed atraumatically to pace and simultaneously map the slow-wave activity in the surrounding area were developed. SPE were applied in pigs in-vivo for gastric pacing along with concurrent high-resolution slow wave mapping as validation. Histology was conducted to assess for tissue damage around the pacing site. SPE were compared against temporary cardiac pacing electrodes (CPE), and hook-shaped pacing electrodes (HPE), for entrainment rate, entrainment threshold, contact quality, and slow-wave propagation patterns. Results: Pacing with SPE (amplitude: 2 mA, pulse width: 100 ms) consistently achieved pacemaker initiation. Histological analysis illustrated no significant tissue damage. SPE resulted in a higher rate of entrainment (64%) than CPE (37%) and HPE (24%), with lower entrainment threshold (25% of CPE and 16% of HPE). High resolution mapping showed that there was no significant difference between the initiated slow-wave propagation speed for SPE and CPE (6.8 ± 0.1 vs 6.8 ± 0.2 mm/s, P>0.05). However, SPE had higher loss of tissue lead contact quality than CPE (42 ± 16 vs 13 ± 10% over 20 min). Conclusion: Pacing with SPE induced a slow-wave pacemaker site without tissue damage. Significance: SPE offered an atraumatic pacing electrode with a significant reduction of power consumption and placement time compared to impaled electrodes. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ELECTRODES
*CARDIAC pacing
*SURFACE impedance
Subjects
Details
- Language :
- English
- ISSN :
- 00189294
- Volume :
- 68
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- IEEE Transactions on Biomedical Engineering
- Publication Type :
- Academic Journal
- Accession number :
- 153068655
- Full Text :
- https://doi.org/10.1109/TBME.2021.3063685