Prurigo nodular: a propósito de un caso tratado con dupilumab.

BACKGROUND: Prurigo nodularis is an inflammatory, chronic and intensely pruritic dermatosis, rare and difficult to treat. It is characterized clinically by hyperkeratotic nodules and papules secondary to repetitive scratching, it can be localized to a body segment or generalized with symmetric distribution. CLINICAL CASE: A 68-year-old male patient with a history of smoking, systemic arterial hypertension and penile carcinoma in complete remission, who had been following up by dermatologists since 2014 for severe prurigo nodularis confirmed by biopsy and with serious quality of life impairment in recent years, without response to the various treatment modalities that exist for the condition and which was contraindicated for immunosuppressant medication. Therefore, it was decided to start therapy with dupilumab using the established dose for the treatment of atopic dermatitis of 600mg subcutaneous induction phase and then doses of 300mg every 2 weeks in the maintenance phase. Monthly follow-up was given finding significant clinical and symptomatic response in the first 3 months, without presenting adverse effects to therapy. CONCLUSIONS: Dupilumab is a good alternative in patients with severe prurigo nodularis with failure of previous treatments or who have contraindications to the use of immunosuppressants. [ABSTRACT FROM AUTHOR]