Toxicity Evaluation of a Mixture Composed of Five Plants: Rosmarinus Officinalis, Ammodaucus Leucotrichus, Chamaemelum Nobile, Petroselinum Crispum, and Lavandula Officinalis Used Traditionally Against Kidney Diseases in Morocc.

Phytochemical analyzes of the mixture were carried out by an assay by HPLC-DAD. The subacute toxicity studies were carried out by oral administration for 28 days, then the evaluations of the relative organ weights, biochemical, hematological, and histopathological analyzes were studied. The analyzes by HPLC-DAD showed the presence of gallic acid, chlorogenic acid, syringic acid, coumaric acid, sinapic acid, 4-Hydroxyphenylacetaldehyde, 3, 4 hydroxycinnamic acid and rutin. The assessment of subacute toxicity presented a statistically significant decrease in body weight and in the relative organ weight of rats treated with the dose of 500 mg / kg. After analyzing the biochemical and hematological parameters, the aqueous extract of the mixture showed functional renal and hepatic toxicity. Histologically, oral administration of the aqueous extract of the mixture at dose of 500 mg / kg showed a histological hepatic change, while the renal tissue presented no change. [ABSTRACT FROM AUTHOR]