ILC3 plasticity in microbiome-mediated tumor progression and immunotherapy.

The precise role of intestinal ILC3s in cancer remains largely unknown. Published in Cell , Goc et al. describe ILC3 function and plasticity in tumors. ILC3s may lose their identity and thus become either ILC1s or exhausting-ILC3s, which could in turn reshape the gut microbiome for colorectal cancer progression and immunotherapy resistance. [ABSTRACT FROM AUTHOR]