Vías de señalización intracelular: Un enfoque hacia la fisiología y patología humana.

For years, much of the advances in medicine and pharmacology have focused on the study of intracellular signaling pathways, giving into a better understanding of the pathologies and formulation of new therapeutic and diagnostic options. This article seeks to provide a synthetic and practical explanation about the function of the main intracellular signaling pathways, exemplifying the importance of each of these through the pathophysiological explanation of various diseases in which there is a prominent role. Among the signaling pathways treated in this work are those activated by protein kinase A (PKA), protein kinase C (PKC), phosphatodylinositol-3-kinase (PI3K), Ca2+/calmodulin-dependent protein kinase (CaMK), the tyrosine kinase (TK) family, the Ras superfamily, as well as the MAPK pathway. In addition, other components of importance for signaling pathways are addressed, such as the ubiquitin-proteosome system, integrins, as well as cyclins, cyclin-dependent kinases (CDK) and other cell cycle regulators. Some of the diseases treated within the text are diabetes mellitus, Alzheimer's and Parkinson's disease, various cardiac arrhythmias, cancer, pulmonary fibrosis, nephrotic syndrome, etc., which are diseases of great relevance in current medicine. [ABSTRACT FROM AUTHOR]