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Comparison of two-year clinical outcomes according to glycemic status and renal function in patients with acute myocardial infarction following implantation of new-generation drug-eluting stents.
- Source :
-
Journal of Diabetes & its Complications . Nov2021, Vol. 35 Issue 11, pN.PAG-N.PAG. 1p. - Publication Year :
- 2021
-
Abstract
- <bold>Aim: </bold>We compared the 2-year clinical outcomes between prediabetes and type 2 diabetes mellitus (T2DM) in patients with acute myocardial infarction (AMI) and chronic kidney disease (CKD) after the successful implantation of new-generation drug-eluting stents.<bold>Methods: </bold>A total of 11,961 AMI patients were classified into group A (estimated glomerular filtration rate [eGFR] < 60 ml/min/1.73m2, n = 2271) and group B (eGFR ≥60 ml/min/1.73 m2, n = 9690). These two groups were sub-classified into normoglycemia, prediabetes, and T2DM. The occurrence of major adverse cardiac events (MACE), defined as all-cause death, recurrent MI (re-MI), and any repeat revascularization was evaluated.<bold>Results: </bold>In group A, the MACE (p = 0.016 and p = 0.004, respectively) and all-cause death (p = 0.044, and p = 0.031, respectively) rates; in groups B, the MACE, all-cause death, and cardiac death rates, were significantly higher in the prediabetes and T2DM groups than in the normoglycemia group. The re-MI and any repeat revascularization rates were significantly higher in the T2DM group than in the normoglycemia group. The MACE, all-cause death, and cardiac death rates in group A were significantly higher than those in all three glycemic subgroups of group B. Both in group A and B, the major clinical outcomes were not significantly different between the prediabetes and T2DM groups.<bold>Conclusions: </bold>AMI patients, both with prediabetes and T2DM, showed a higher mortality rate than those with normoglycemia regardless of the degree of eGFR. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10568727
- Volume :
- 35
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Journal of Diabetes & its Complications
- Publication Type :
- Academic Journal
- Accession number :
- 152847875
- Full Text :
- https://doi.org/10.1016/j.jdiacomp.2021.108019