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Rhodium-Catalyzed Direct Allylation of Simple Arenes by Using Gem -Difluorinated Cyclopropanes as Allyl Surrogates.
- Source :
-
Synlett . 2021, Vol. 32 Issue 17, p1675-1682. 8p. - Publication Year :
- 2021
-
Abstract
- Gem -difluorinated cyclopropanes have become an important type of allyl surrogate in transition-metal-catalyzed ring-opening processes, as demonstrated recently through various important advances, especially with palladium catalysis. The versatile fluorinated allyl species generated in this way from gem -difluorinated cyclopropanes exhibit unique advantages compared with conventional allyl sources. By using gem -difluorinated cyclopropanes as allyl surrogates, we achieved a direct allylation of simple arenes through rhodium catalysis under mild conditions. This transformation permits directing-group-free allylation of simple arenes, including electron-neutral, electron-rich, and electron-deficient ones. Here, we give a brief introduction to this area and we discuss our thoughts regarding our recent work and its design. 1 Introduction 2 Our Design 3 Condition Optimization and Substrate Scope 4 Applications in Synthesis 5 Mechanistic Discussions 6 Conclusion and Outlook [ABSTRACT FROM AUTHOR]
- Subjects :
- *ALLYLATION
*CATALYSIS
*RHODIUM
*AROMATIC compounds
*WORK design
*PALLADIUM
Subjects
Details
- Language :
- English
- ISSN :
- 09365214
- Volume :
- 32
- Issue :
- 17
- Database :
- Academic Search Index
- Journal :
- Synlett
- Publication Type :
- Academic Journal
- Accession number :
- 152843416
- Full Text :
- https://doi.org/10.1055/a-1536-2738