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Eosinophils are dispensable for development of MOG35–55-induced experimental autoimmune encephalomyelitis in mice.
- Source :
-
Immunology Letters . Nov2021, Vol. 239, p72-76. 5p. - Publication Year :
- 2021
-
Abstract
- • Enhanced eosinophil numbers in the spinal cord in the course of EAE. • Absence of eosinophils has no impact on clinical development or severity of EAE. • Spinal cord inflammation and demyelination is not affected by eosinophil deficiency. Experimental autoimmune encephalomyelitis (EAE) represents the mouse model of multiple sclerosis, a devastating neurological disorder. EAE development and progression involves the infiltration of different immune cells into the brain and spinal cord. However, less is known about a potential role of eosinophil granulocytes for EAE disease pathogenesis. In the present study, we found enhanced eosinophil abundance accompanied by increased concentration of the eosinophil chemoattractant eotaxin-1 in the spinal cord in the course of EAE induced in C57BL/6 mice by immunization with MOG 35–55 peptide. However, the absence of eosinophils did not affect neuroinflammation, demyelination and clinical development or severity of EAE, as assessed in ∆dblGATA1 eosinophil-deficient mice. Taken together, despite their enhanced abundance in the inflamed spinal cord during disease progression, eosinophils were dispensable for EAE development. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01652478
- Volume :
- 239
- Database :
- Academic Search Index
- Journal :
- Immunology Letters
- Publication Type :
- Academic Journal
- Accession number :
- 152814809
- Full Text :
- https://doi.org/10.1016/j.imlet.2021.09.001