组织修复和再生领域浓缩生长因子的应用优势.

BACKGROUND: As the latest generation of autologous platelet concentrate biologics, concentrated growth factor has become a research hotspot in the field of tissue repair and regeneration due to its natural fibrin scaffold and abundant endogenous growth factors. OBJECTIVE: To summarize the research progress of concentrated growth factors in the field of tissue repair and regeneration, as well as discuss the existing problems in the current research stage, in order to provide new reference ideas for the follow-up research of concentrated growth factors. METHODS: This article used “concentrated growth factor, CGF, stem cells, tissue repair, tissue regeneration” as search terms. A comprehensive search was conducted on PubMed, EMbase, Medline, and CNKI. The relevant research evidence of the application of concentrated growth factor in the field of tissue repair and regeneration in the past 10 years were collected and summarized. The literature was screened based on strict inclusion and exclusion criteria. Finally, 96 articles were included. RESULTS AND CONCLUSION: (1) This article summarized the research progress of concentrated growth factor from four aspects: the specific method of preparation and application of concentrated growth factor, the principle of concentrated growth factor promoting tissue repair and regeneration, the effect on cell proliferation and differentiation in vitro, and the repair and reconstruction of tissue in vivo, and discussed the current research the existing problems. (2) Concentrated growth factor is an autologous bioactive factor with potential in the field of tissue repair and regeneration. The preparation method is simple and the application method is flexible and changeable. It is completely taken from autologous blood, so that it has great biocompatibility and few immune rejection reactions. (3) The core structure of concentrated growth factor includes a natural fibrin scaffold and a variety of endogenous growth factors, which can promote the proliferation, migration and differentiation of a variety of stem cells in vitro. (4) Concentrated growth factors can promote the repair of bone defects in vivo, and the local growth factor slow-release system constructed by combining it with tissue engineering materials is an effective way to extend the slow-release time of growth factors. (5) Concentrated growth factors have shown great effects in promoting soft tissue repairing, anti-skin photoaging, and reducing postoperative complications. It has become one of the preferred options for personalized treatment of autologous bioactive preparations. [ABSTRACT FROM AUTHOR]