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Enantioselective Organocatalytic Synthesis of 1,2,3‐Trisubstituted Cyclopentanes.
- Source :
-
European Journal of Organic Chemistry . 9/24/2021, Vol. 2021 Issue 36, p5080-5089. 10p. - Publication Year :
- 2021
-
Abstract
- An organocatalytic asymmetric domino Michael/α‐alkylation reaction between enals and non‐stabilized alkyl halides has been developed. Chiral secondary amine catalyzed cyclization reaction of 1‐bromo‐3‐nitropropane with α,β‐unsaturated aldehydes provides 1,2,3‐trisubstituted cyclopentane carbaldehydes with high diastereo‐ (dr up to 8 : 1) and enantioselectivities (ee up to 96 %). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1434193X
- Volume :
- 2021
- Issue :
- 36
- Database :
- Academic Search Index
- Journal :
- European Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 152652982
- Full Text :
- https://doi.org/10.1002/ejoc.202100841