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Global dynamics of a delayed latent virus model with both virus-to-cell and cell-to-cell transmissions and humoral immunity.
- Source :
-
Journal of Inequalities & Applications . 9/22/2021, Vol. 2021 Issue 1, p1-19. 19p. - Publication Year :
- 2021
-
Abstract
- In this paper, the dynamical behaviors for multiple delayed latent virus model with virus-to-cell infection and cell-to-cell transmissions and humoral immunity are investigated. The virus-to-cell and cell-to-cell incidence rates are modeled by general nonlinear functions. The basic reproduction number R 0 and the humoral immune response number R 1 are calculated and proved to be threshold conditions determining the local and global properties of the virus model. The existence of Hopf bifurcation with immune delay as a bifurcation parameter is presented, and the effects of some key parameters on viral dynamics are revealed by numerical simulations. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10255834
- Volume :
- 2021
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Inequalities & Applications
- Publication Type :
- Academic Journal
- Accession number :
- 152580956
- Full Text :
- https://doi.org/10.1186/s13660-021-02691-y