Back to Search
Start Over
Effects of inorganic nitrate on ischaemia-reperfusion injury after coronary artery bypass surgery.
- Source :
-
BJA: The British Journal of Anaesthesia . Oct2021, Vol. 127 Issue 4, p547-555. 9p. - Publication Year :
- 2021
-
Abstract
- <bold>Background: </bold>Nitric oxide (NO) is an important signalling molecule in the cardiovascular system with protective properties in ischaemia-reperfusion injury. Inorganic nitrate, an oxidation product of endogenous NO production and a constituent in our diet, can be recycled back to bioactive NO. We investigated if preoperative administration of inorganic nitrate could reduce troponin T release and other plasma markers of injury to the heart, liver, kidney, and brain in patients undergoing cardiac surgery.<bold>Methods: </bold>This single-centre, randomised, double-blind, placebo-controlled trial included 82 patients undergoing coronary artery bypass surgery with cardiopulmonary bypass. Oral sodium nitrate (700 mg×2) or placebo (NaCl) were administered before surgery. Biomarkers of ischaemia-reperfusion injury and plasma nitrate and nitrite were collected before and up to 72 h after surgery. Troponin T release was our predefined primary endpoint and biomarkers of renal, liver, and brain injury were secondary endpoints.<bold>Results: </bold>Plasma concentrations of nitrate and nitrite were elevated in nitrate-treated patients compared with placebo. The 72-h release of troponin T did not differ between groups. Other plasma biomarkers of organ injury were also similar between groups. Blood loss was not a predefined outcome parameter, but perioperative bleeding was 18% less in nitrate-treated patients compared with controls.<bold>Conclusion: </bold>Preoperative administration of inorganic nitrate did not influence troponin T release or other plasma biomarkers of organ injury in cardiac surgery.<bold>Clinical Trial Registration: </bold>NCT01348971. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CARDIOPULMONARY bypass
*CORONARY artery surgery
*CORONARY artery bypass
*RANDOMIZED controlled trials
*HEART injuries
*CARDIAC surgery
*TROPONIN
*PREOPERATIVE care
*SURGICAL blood loss
*RESEARCH
*RESEARCH methodology
*NITRATES
*MEDICAL cooperation
*EVALUATION research
*MYOCARDIAL reperfusion complications
*COMPARATIVE studies
*BLIND experiment
*NITRIC oxide
Subjects
Details
- Language :
- English
- ISSN :
- 00070912
- Volume :
- 127
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- BJA: The British Journal of Anaesthesia
- Publication Type :
- Academic Journal
- Accession number :
- 152514407
- Full Text :
- https://doi.org/10.1016/j.bja.2021.06.046