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Effects of inorganic nitrate on ischaemia-reperfusion injury after coronary artery bypass surgery.

Authors :
Eriksson, Karin E.
Eidhagen, Fredrik
Liska, Jan
Franco-Cereceda, Anders
Lundberg, Jon O.
Weitzberg, Eddie
Source :
BJA: The British Journal of Anaesthesia. Oct2021, Vol. 127 Issue 4, p547-555. 9p.
Publication Year :
2021

Abstract

<bold>Background: </bold>Nitric oxide (NO) is an important signalling molecule in the cardiovascular system with protective properties in ischaemia-reperfusion injury. Inorganic nitrate, an oxidation product of endogenous NO production and a constituent in our diet, can be recycled back to bioactive NO. We investigated if preoperative administration of inorganic nitrate could reduce troponin T release and other plasma markers of injury to the heart, liver, kidney, and brain in patients undergoing cardiac surgery.<bold>Methods: </bold>This single-centre, randomised, double-blind, placebo-controlled trial included 82 patients undergoing coronary artery bypass surgery with cardiopulmonary bypass. Oral sodium nitrate (700 mg×2) or placebo (NaCl) were administered before surgery. Biomarkers of ischaemia-reperfusion injury and plasma nitrate and nitrite were collected before and up to 72 h after surgery. Troponin T release was our predefined primary endpoint and biomarkers of renal, liver, and brain injury were secondary endpoints.<bold>Results: </bold>Plasma concentrations of nitrate and nitrite were elevated in nitrate-treated patients compared with placebo. The 72-h release of troponin T did not differ between groups. Other plasma biomarkers of organ injury were also similar between groups. Blood loss was not a predefined outcome parameter, but perioperative bleeding was 18% less in nitrate-treated patients compared with controls.<bold>Conclusion: </bold>Preoperative administration of inorganic nitrate did not influence troponin T release or other plasma biomarkers of organ injury in cardiac surgery.<bold>Clinical Trial Registration: </bold>NCT01348971. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00070912
Volume :
127
Issue :
4
Database :
Academic Search Index
Journal :
BJA: The British Journal of Anaesthesia
Publication Type :
Academic Journal
Accession number :
152514407
Full Text :
https://doi.org/10.1016/j.bja.2021.06.046