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Photoredox/nickel dual-catalyzed regioselective alkylation of propargylic carbonates for trisubstituted allenes.
- Source :
-
Chemical Communications . 9/21/2021, Vol. 57 Issue 74, p9390-9393. 4p. - Publication Year :
- 2021
-
Abstract
- Herein, a highly regioselective alkylation of propargylic carbonates for trisubstituted allenes with alkyl 1,4-dihydropyridine derivatives (1,4-DHPs) is developed via a photoredox/nickel dual-catalyzed process, which represents the first direct approach to access alkylated allene products without alkyl organometallic reagents. This method features a broad substrate scope and mild conditions. A hypothetical mechanism with an alkyl radical and an allenyl Ni(III) species is proposed. Benzylation products were also obtained to be the complement building blocks for the potential synthesis of pharmaceuticals. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ALKYL radicals
*NICKEL
*ALLENE
*CARBONATES
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 57
- Issue :
- 74
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 152489204
- Full Text :
- https://doi.org/10.1039/d1cc03303d