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Real‐time Tracking and Sensing of Cu+ and Cu2+ with a Single SERS Probe in the Live Brain: Toward Understanding Why Copper Ions Were Increased upon Ischemia.
- Source :
-
Angewandte Chemie International Edition . 9/20/2021, Vol. 60 Issue 39, p21351-21359. 9p. - Publication Year :
- 2021
-
Abstract
- The imbalance of Cu+ and Cu2+ in the brain is closely related to neurodegenerative diseases. However, it still lacks of effective analytical methods for simultaneously determining the concentrations of Cu+ and Cu2+. Herein, we created a novel SERS probe (CuSP) to real‐time track and accurately quantify extracellular concentrations of Cu+ and Cu2+ in the live brain. The present CuSP probe demonstrated specific ability for recognition of Cu+ and Cu2+ in a dual‐recognition mode. Then, a microarray consisting of 8 CuSP probes with high tempo‐spatial resolution and good accuracy was constructed for tracking and simultaneously biosensing of Cu+ and Cu2+ in the cerebral cortex of living brain. Using our powerful tool, it was found that that the concentrations of Cu2+ and Cu+ were increased by ≈4.26 and ≈1.80 times upon ischemia, respectively. Three routes were first discovered for understanding the mechanisms of the increased concentrations of Cu+ and Cu2+ during ischemia. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COPPER ions
*ISCHEMIA
*CEREBRAL cortex
*NEURODEGENERATION
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 60
- Issue :
- 39
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 152442587
- Full Text :
- https://doi.org/10.1002/anie.202106193