Toxoplasma gondii seroprevalence among tuberculosis patients: A systematic review and meta-analysis.

Toxoplasma gondii and Mycobacterium tuberculosis are intracellular pathogens, both infecting a substantial proportion of human population. We conducted a systematic review and meta-analysis to estimate the pooled T. gondii seroprevalence in tuberculosis patients. Three international databases were systematically searched for literature on prevalence of T. gondii in tuberculosis patients. A total of 1389 documents were identified, and eight papers were eligible to be included in the systematic review and meta-analysis. Geographical data gaps were evident, as no studies were identified from many countries where both infections are important. The pooled seroprevalence of IgG, IgM, and both IgG and IgM antibodies against T. gondii in tuberculosis patients were estimated to be 35.9% (95% confidence interval [CI], 19.3–56.7%), 35.0% (95% CI, 3.0–90.3%), and 13.4% (95% CI, 2.4–49.0%), respectively. In the included case-control studies, the pooled T. gondii seroprevalence (proportion anti- T. gondii IgG antibody positive) was higher in tuberculosis patients than in their controls, with an odds ratio by random effects model of 1.63 (95% CI, 1.28–2.08). The results of our work suggest an association between T. gondii seropositivity and being a tuberculosis patient, which should however be interpreted with caution because the timeline of the infections and the disease process are not accounted for. Our work showed that T. gondii seropositivity, indicating chronic infection with the zoonotic parasite, was relatively common among tuberculosis patients. • T. gondii and M. tuberculosis are intracellular pathogens that are able to cause chronic infections as well as severe disease in humans. • We conducted a systematic review and meta-analysis to estimate pooled T. gondii seroprevalence among tuberculosis patients. • The seroprevalence estimate of IgG antibodies against T. gondii among tuberculosis patients was 35.9% (95% confidence interval 19.3–56.7%). • In the case-control studies, T. gondii seroprevalence was 29.5% among tuberculosis patients and 17.2% among controls, and the odds ratio was 1.63 (95% CI 1.28–2.08). • The results showed that T. gondii seropositivity was relatively common among tuberculosis patients. [ABSTRACT FROM AUTHOR]