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1142-P: Efficacy and Safety of Antidiabetes Treatment in Adjunct to Insulin in Type 1 Diabetes.
- Source :
-
Diabetes . 2019 Supplement, Vol. 68, pN.PAG-N.PAG. 1p. - Publication Year :
- 2019
-
Abstract
- Aims: To evaluate the efficacy and safety of antidiabetes treatment in adjunct to insulin in type 1 diabetes. Methods: A systematic search of MEDLINE, Embase and Cochrane Central Register of Controlled Trials was made from the beginning date to June 2018. Results: A total of 48 studies were included in the meta-analysis. Compared with placebo, treatment with metformin, treatment with a-glucosidase inhibitor (AGI), treatment with GLP-1 receptor agonist, treatment with SGLT2 inhibitor, treatment with pramlintide all showed significant decrease in HbA1c from baseline (Table 1). Compared with placebo, treatment with metformin, treatment with GLP-1 receptor agonist, treatment with SGLT2 inhibitor, treatment with pramlintide all resulted in significant decrease in insulin dosage from baseline (Table 1). Conclusion: Compared with placebo, in type 1 diabetes patients, in adjunctive to insulin treatment, treatment with metformin, treatment with GLP-1 receptor agonist, treatment with SGLT2 inhibitor, treatment with pramlintide all resulted in significant decrease in HbA1c and insulin dosage from baseline. Disclosure: X. Cai: None. W. Yang: None. S. Zhang: None. L. Ji: Advisory Panel; Self; AstraZeneca. Consultant; Self; AstraZeneca, Bayer AG, Boehringer Ingelheim International GmbH, Bristol-Myers Squibb Company, Eli Lilly and Company, Merck KGaA, Merck Sharp & Dohme Corp., Novartis AG, Novo Nordisk A/S, Roche Pharma, Sanofi, Takeda Pharmaceutical Company Limited. Research Support; Self; AstraZeneca, Bristol-Myers Squibb Company, Eli Lilly and Company, Merck Sharp & Dohme Corp., Novartis AG, Roche Pharma, Sanofi. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00121797
- Volume :
- 68
- Database :
- Academic Search Index
- Journal :
- Diabetes
- Publication Type :
- Academic Journal
- Accession number :
- 152325735
- Full Text :
- https://doi.org/10.2337/db19-1142-P