调节破骨细胞功能的相关信号分子的研究进展.

The ability of osteoclasts to erode bone is an important cellular function of bone development and bone remodeling. Most pathological bone diseases, such as osteoporosis, reflect an increase in the number, activity and absorptive capacity of osteoclasts. The increase of osteoclast number and activity will lead to the damage of bone structure and the decrease of bone mass, which are the common characteristics of bone diseases such as osteoporosis. Therefore, inhibiting osteoclast differentiation is one of the treatment strategies to prevent and / or to treat bone diseases and related fractures. Elucidating the molecular mechanism of osteoclast-induced bone resorption and the signal molecules regulating osteoclast activity will provide reference for drug development for bone diseases by inhibiting bone resorption. In this paper, the recent research progress of osteoclast differentiation, activity, and absorption function signal molecules is reviewed. [ABSTRACT FROM AUTHOR]