Rectal bleeding and cow's milk protein‐induced allergic proctocolitis: A prospective study.

Although seroconversion in IgE-mediated forms is rare since it affected only one of our patients, OFC-T should be preceded by a specific IgE assay or a skin prick test (unlike OFC-D7), and OFC-T may be performed at home only in the event of negative results. Eighteen (31.0%) patients experienced objective and/or subjective significant and persistent symptoms during OFC-D and were therefore considered to have FPIAP-CMP. Serological tests for allergy were performed in 34 patients (58.6%) during the first consultation ( I n i = 10, 55.6% in the FPIAP-CMP group; I n i = 24, 60.0% in the non-FPIAP-CMP group). At diagnosis, all the tested patients had CMP-specific IgE below 0.35 kU/L, except one who had a betalactoglobulin-specific IgE of 0.54 kU/L in the non-FPIAP-CMP group, without IgE-mediated clinical manifestations. [Extracted from the article]