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Clinical trials of germline gene editing: The exploitation problem.
- Source :
-
Bioethics . Sep2021, Vol. 35 Issue 7, p688-695. 8p. - Publication Year :
- 2021
-
Abstract
- The birth of the world's first genetically edited babies in 2018 provoked considerable ethical outrage. Nonetheless, many scientists and bioethicists now advocate the pursuit of clinical uses of human germline gene editing. Progress towards this goal will require research, including clinical trials where genetically edited embryos are implanted into a woman's uterus, gestated, and brought to term. This paper argues that such trials would likely conflict with the fundamental research ethical requirement of nonâexploitation. This is because they would expose people who are in a vulnerable situation to risks and burdens that are substantial and not obviously offset by compensating benefits. I consider how the potential for exploitation in such trials might be mitigated, arguing that a feasible and justifiable approach is not easily found. If this analysis is correct, there is a significant ethical obstacle on the path towards clinical use of human germline gene editing. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02699702
- Volume :
- 35
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Bioethics
- Publication Type :
- Academic Journal
- Accession number :
- 152209171
- Full Text :
- https://doi.org/10.1111/bioe.12903