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Notch3 is required for arterial identity and maturation of vascular smooth muscle cells.
- Source :
-
Genes & Development . 11/15/2004, Vol. 18 Issue 22, p2730-2735. 6p. 4 Color Photographs, 1 Graph. - Publication Year :
- 2004
-
Abstract
- Formation of a fully functional artery proceeds through a multistep process. Here we show that Notch3 is required to generate functional arteries in mice by regulating arterial differentiation and maturation of vascular smooth muscle cells (vSMC). In adult Notch3-/- mice distal arteries exhibit structural defects and arterial myogenic responses are defective. The postnatal maturation stage of vSMC is deficient in Notch3-/- mice. We further show that Notch3 is required for arterial specification of vSMC but not of endothelial cells. Our data reveal Notch3 to be the first cell-autonomous regulator of arterial differentiation and maturation of vSMC. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ARTERIES
*MICE
*MUSCLE cells
*CELLS
*EXCITABLE membranes
*MYOGENESIS
Subjects
Details
- Language :
- English
- ISSN :
- 08909369
- Volume :
- 18
- Issue :
- 22
- Database :
- Academic Search Index
- Journal :
- Genes & Development
- Publication Type :
- Academic Journal
- Accession number :
- 15210158
- Full Text :
- https://doi.org/10.1101/gad.308904