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Efficacy and Safety of Dapagliflozin by Baseline Glycemic Status: A Prespecified Analysis From the DAPA-CKD Trial.
- Source :
-
Diabetes Care . Aug2021, Vol. 44 Issue 8, p1894-1897. 4p. - Publication Year :
- 2021
-
Abstract
- <bold>Objective: </bold>The Dapagliflozin and Prevention of Adverse outcomes in Chronic Kidney Disease (DAPA-CKD) study demonstrated risk reduction for kidney and cardiovascular outcomes with dapagliflozin versus placebo in participants with chronic kidney disease (CKD) with and without diabetes. We compared outcomes according to baseline glycemic status.<bold>Research Design and Methods: </bold>We enrolled participants with CKD, estimated glomerular filtration rate (eGFR) 25-75 mL/min/1.73 m2, and urinary albumin-to-creatinine ratio 200-5,000 mg/g. The primary composite end point was sustained eGFR decline ≥50%, end-stage kidney disease, or kidney or cardiovascular death.<bold>Results: </bold>Of 4,304 participants, 738 had normoglycemia, 660 had prediabetes, and 2,906 had type 2 diabetes. The effect of dapagliflozin on the primary outcome was consistent (P for interaction = 0.19) in normoglycemia (hazard ratio [HR] 0.62 [95% CI 0.39, 1.01]), prediabetes (HR 0.37 [0.21, 0.66]), and type 2 diabetes (HR 0.64 [0.52, 0.79]). We found no evidence for effect modification on any outcome. Adverse events were similar, with no major hypoglycemia or ketoacidosis in participants with normoglycemia or prediabetes.<bold>Conclusions: </bold>Dapagliflozin safely reduced kidney and cardiovascular events independent of baseline glycemic status. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CHRONIC kidney failure
*TYPE 2 diabetes
*DAPAGLIFLOZIN
*CARDIOVASCULAR diseases
*EPIDERMAL growth factor receptors
*CARDIOVASCULAR disease prevention
*BENZENE
*GLOMERULAR filtration rate
*RESEARCH
*RESEARCH methodology
*GLYCOSIDES
*MEDICAL cooperation
*EVALUATION research
*COMPARATIVE studies
*DISEASE complications
CHRONIC kidney failure complications
Subjects
Details
- Language :
- English
- ISSN :
- 01495992
- Volume :
- 44
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Diabetes Care
- Publication Type :
- Academic Journal
- Accession number :
- 152055358
- Full Text :
- https://doi.org/10.2337/dc21-0300