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A case of a primary myelofibrosis with progression and related literature review of progression phase genetics.
- Source :
-
International Journal of Laboratory Hematology . 2021 Supplement, Vol. 43, p78-81. 4p. - Publication Year :
- 2021
-
Abstract
- Philadelphia (BCR- ABL)- negative myeloproliferative neoplasms (MPNs) include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). MPN can transform into an accelerated or a blast phase, which is associated with poor response to standard therapy and low overall median survival. We present an interesting case of a patient with a history of PMF and progression and summarize the current studies on genetic features of myeloproliferative neoplasms in blast phase (MPN- BP) with an emphasis on PMF. Although MPN- BP show ≥20% blasts in peripheral blood or bone marrow, it is not considered as acute myeloid leukemia (AML) according to the WHO classification. While MPNs- BP typically lack genetic mutations seen in de novo AML, they commonly harbor IDH1/2, SRSF2, ASXL1, and TP53 mutations, similar to the genetic profiles of acute myeloid leukemia with myelodysplasia-related changes (AML- MRC). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17515521
- Volume :
- 43
- Database :
- Academic Search Index
- Journal :
- International Journal of Laboratory Hematology
- Publication Type :
- Academic Journal
- Accession number :
- 152033165
- Full Text :
- https://doi.org/10.1111/ijlh.13565