肾病综合征患者血清同型半胱氨酸、D-二聚体和B型钠尿肽水平表达及与血栓栓塞的关系分析.

Objective: To investigate the levels of serum homocysteine(Hcy), D-Dimer(D-D) and B-type natriuretic peptide(BNP) in patients with nephrotic syndrome(NS) and their relationship with thromboembolism (TE). Methods: 241 patients with NS admitted to our hospital from January 2017 to January 2019 were selected and divided into TE group (n=56) and non TE group (n=185) according to whether they were complicated with TE or not. Another 65 healthy people were selected as the control group. The levels of serum Hcy, D-D and BNP in each group were compared.The influencing factors of NS patients complicated with TE were analyzed by multivariate logistic regression. Results: There were significant differences in serum Hcy, D-D and BNP levels among the three groups (P<0.05). The serum levels of Hcy, D-D and BNP in TE group were significantly higher than those in non TE group. The serum levels of Hcy, D-D and BNP in non TE group were significantly higher than those in control group (P<0.05). The proportion of history of hypertension,history of diuretic use, history of glucocorticoid use, BUN and 24hUPQ levels in TE group were significantly higher than those in non TE group (P<0.05). Multivariate logistic regression analysis showed that Hcy, D-D, BNP and 24hUPQ were independent influencing factors of NS patients complicated with TE (P<0.05). ROC curve showed that the AUC of serum Hcy+D-D+BNP level in diagnosing NS patients complicated with TE was significantly higher than that of serum Hcy, D-D and BNP alone, and the sensitivity and specificity were also higher than that of each index alone. Conclusion: The serum levels of Hcy, D-D and BNP in patients with NS were significantly increased, and further increased after combined with TE. The serum levels of Hcy, D-D and BNP were risk factors for the occurrence of TE in patients with NS, and combined detection can improve the diagnostic value. [ABSTRACT FROM AUTHOR]