血清SAA、CRP、SIRT1水平与新生儿坏死性小肠结肠炎疾病进展的关系及其诊断价值分析.

Objective: To investigate the relationship between serum amyloid A (SAA), C-reactive protein (CRP) and silent information regulator 1 (SIRT1) levels and the progression of neonatal necrotizing enterocolitis and their diagnostic value. Methods: 100 cases of necrotizing enterocolitis treated in the neonatal department of Wuhan Children's Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology from March 2017 to October 2018 were selected as the observation group. Another 100 healthy newborns born in Wuhan Children's Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology were selected as the control group. The serum SAA, CRP and SIRT1 levels were measured in each group. Serum SAA, CRP and SIRT1 levels were compared among children with different corrected Bell stages. Spearman correlation analysis was used to observe the correlation between serum SAA, CRP and SIRT1 levels and corrected Bell staging in children in the group. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of three indexes for necrotizing enterocolitis. Results: Compared with the control group, serum SAA and CRP levels were significantly increased in the observation group, while SIRT1 levels were significantly decreased(P<0.05). Comparison of the serum SAA, CRP and SIRT1 levels cin children with different corrected Bell stages showed statistically significant differences by one-way analysis of variance (P<0.05). The serum SAA and CRP levels of the children with corrected Bell stage I, II and III increased in turn, and the serum SIRT1 level of the children with corrected Bell stage I, II and III decreased in turn (all P<0.05). Corrected Bell staging was positively correlated with serum SAA and CRP levels(P＜0.05). Corrected Bell staging was neg-atively correlated with serum SIRT1 level (P＜0.05). The area under curve (AUC) value, sensitivity, specificity and Youden index of the combined detection of three indexes were higher than those of the three indexes alone. Conclusion: The serum SAA and CRP levels in newborns with necrotizing enterocolitis are increased, while the SIRT1 level is decreased, which are related to the progression of neonatal necrotizing enterocolitis. The combined value of the three indexes in the diagnosis of necrotizing enterocolitis is relatively high. [ABSTRACT FROM AUTHOR]