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Persistence of Antibody and Cellular Immune Responses in COVID-19 patients over Nine Months after Infection.
- Source :
-
Journal of Infectious Diseases . 8/15/2021, Vol. 224 Issue 4, p586-594. 9p. - Publication Year :
- 2021
-
Abstract
- <bold>Background: </bold>The duration of humoral and T and cell response after the infection of SARS-CoV-2 remains unclear.<bold>Methods: </bold>We performed a cross-sectional study to assess the virus-specific antibody and memory T and B cell responses in COVID-19 patients up to 343 days after infection. Neutralizing antibodies and antibodies against the receptor-binding domain, spike, and nucleoprotein of SARS-CoV-2 were measured. Virus-specific memory T and B cell responses were analyzed.<bold>Results: </bold>We enrolled 59 COVID-19 patients, including 38 moderate, 16 mild, and five asymptomatic patients; 31 (52.5%) were men, and 28 (47.5%) were women. The median age was 41 (interquartile range [IQR]: 30-55). The median day from symptom onset to enrollment was 317 days (range 257 to 343 days). We found that approximately 90% of patients still have detectable IgG antibodies against spike and nucleocapsid proteins and neutralizing antibodies against pseudovirus, whereas ~60% of patients had detectable IgG antibodies against receptor binding domain and surrogate virus-neutralizing antibodies. SARS-CoV-2-specific IgG + memory B cell and IFN-γ secreting T cell responses were detectable in over 70% of patients.<bold>Conclusions: </bold>SARS-CoV-2-specific immune memory response persists in most patients nearly one year after infection, which provides a promising sign for prevention from reinfection and vaccination strategy. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COVID-19
*COVID-19 pandemic
*HUMORAL immunity
*IMMUNE response
*IMMUNOLOGIC memory
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 224
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 151977211
- Full Text :
- https://doi.org/10.1093/infdis/jiab255