Utilization and perioperative outcome of minimally invasive pelvic exenteration in gynecologic malignancies: a national study in the United States.

To examine characteristics and short-term perioperative outcomes related to minimally invasive pelvic exenteration for gynecologic malignancy. This comparative effectiveness study is a retrospective population-based analysis of the National Inpatient Sample from 10/2009-9/2015. Women with cervical, uterine, vaginal, and vulvar malignancies who underwent pelvic exenteration were evaluated based on the use of laparoscopic or robotic-assisted surgery. Patient demographics and intraoperative/postoperative complications related to a minimally invasive surgical approach were assessed. Among 1,159 women who underwent pelvic exenteration, 39 (3.4%) had the procedure performed via a minimally invasive approach. The majority of minimally invasive cases were robotic-assisted (n =25, 64.1%). Women in the minimally invasive group were more likely to be White and have cervical cancer, but less likely to be obese and receive vaginal reconstruction or colostomy when compared to those in the open surgery group (all, P <0.05). Overall perioperative complication rates were similar between the minimally invasive and open surgery groups (74.4% versus 78.9%, P =0.549), but the minimally invasive group had a decreased risk of high-risk complications compared to the open surgery group (adjusted-odds ratio 0.24, 95% confidence interval 0.09-0.65). Specifically, a minimally invasive approach was associated with decreased incidence of hemorrhage and sepsis compared to an open approach (all, P <0.05). The minimally invasive group had a shorter length of stay (median, 9 versus 15 days) and lower total charge (median, $118,711 versus $213,640) compared to the open surgery group (both, P<0.001). Laparotomy remains the main surgical approach for pelvic exenteration for gynecologic malignancy in the United States. Minimally invasive pelvic exenteration need to be carefully evaluated before widely adopting this approach. [ABSTRACT FROM AUTHOR]