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Synthesis of γ Phase and Amorphous Solid Dispersion of Glycine from α-Glycine During the Solvent-Free Ball Milling Process.
- Source :
-
Journal of Pharmaceutical Sciences . Sep2021, Vol. 110 Issue 9, p3171-3175. 5p. - Publication Year :
- 2021
-
Abstract
- Nano α-glycine crystals, γ-glycine crystals, and amorphous solid dispersion (ASD) of glycine were prepared through solvent-free ball milling of commercial α-glycine. The solid-state polymorph conversion of glycine from α to γ was completely realized by ball milling with 0.2 wt.% NaCl for 1 h or by ball milling with 0.02 wt.% NaCl for 1 h with subsequent storage for one week. The ASD of glycine was prepared by ball milling α-glycine with an equal amount of CaCl 2 for 1 h. We studied the effect of inorganic salt types and their concentrations on the extent of polymorph conversion and amorphization of glycine in our experiments. This solvent-free ball milling method could be used for the synthesis of polymorphs and amorphous phase of drugs and other organic materials. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AMORPHOUS substances
*BALL mills
*GLYCINE
*DISPERSION (Chemistry)
*AMORPHIZATION
Subjects
Details
- Language :
- English
- ISSN :
- 00223549
- Volume :
- 110
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Journal of Pharmaceutical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 151855429
- Full Text :
- https://doi.org/10.1016/j.xphs.2021.06.023