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Human papillomavirus in retinoblastoma: A tertiary eye care center study from South India.
- Source :
-
Indian Journal of Ophthalmology . Aug2021, Vol. 69 Issue 8, p2111-2115. 5p. - Publication Year :
- 2021
-
Abstract
- <bold>Purpose: </bold>This study is aimed to investigate the presence of Human papillomavirus (HPV) DNA in tumors obtained from sporadic retinoblastoma patients.<bold>Methods: </bold>One hundred six tumor tissues obtained from sporadic RB patients were analyzed for HPV infection by use of both seminested PCR and real-time quantitative PCR.<bold>Results: </bold>Of 106 RB patients, 55 were male and 51 were female. The mean age at diagnosis was 26.77 ± 15.36 (mean ± Std. dev) months. Almost all patients presented with leukocoria. Molecular investigation by different methods revealed no HPV positivity in any tumor genome.<bold>Conclusion: </bold>Our study demonstrates no association between HPV and RB, postulating HPV may not be a major risk factor in the etiology of RB. [ABSTRACT FROM AUTHOR]
- Subjects :
- *EYE care
*RETINOBLASTOMA
*PAPILLOMAVIRUSES
*TERTIARY care
*DIAGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 03014738
- Volume :
- 69
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Indian Journal of Ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 151831017
- Full Text :
- https://doi.org/10.4103/ijo.IJO_106_21