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Exploring the Contribution of Myelin Content in Normal Appearing White Matter to Cognitive Outcomes in Cerebral Small Vessel Disease.

Authors :
Dao, Elizabeth
Tam, Roger
Hsiung, Ging-Yuek R.
ten Brinke, Lisanne
Crockett, Rachel
Barha, Cindy K.
Yoo, Youngjin
Al Keridy, Walid
Doherty, Stephanie H.
Laule, Cornelia
MacKay, Alex L.
Liu-Ambrose, Teresa
Source :
Journal of Alzheimer's Disease. 2021, Vol. 80 Issue 1, p91-101. 11p.
Publication Year :
2021

Abstract

<bold>Background: </bold>Myelin damage is a salient feature in cerebral small vessel disease (cSVD). Of note, myelin damage extends into the normal appearing white matter (NAWM). Currently, the specific role of myelin content in cognition is poorly understood.<bold>Objective: </bold>The objective of this exploratory study was to investigate the association between NAWM myelin and cognitive function in older adults with cSVD.<bold>Methods: </bold>This exploratory study included 55 participants with cSVD. NAWM myelin was measured using myelin water imaging and was quantified as myelin water fraction (MWF). Assessment of cognitive function included processing speed (Trail Making Test Part A), set shifting (Trail Making Test Part B minus A), working memory (Verbal Digit Span Backwards Test), and inhibition (Stroop Test). Multiple linear regression analyses assessed the contribution of NAWM MWF on cognitive outcomes controlling for age, education, and total white matter hyperintensity volume. The overall alpha was set at ≤0.05.<bold>Results: </bold>After accounting for age, education, and total white matter hyperintensity volume, lower NAWM MWF was significantly associated with slower processing speed (β  = -0.29, p = 0.037) and poorer working memory (β= 0.30, p = 0.048). NAWM MWF was not significantly associated with set shifting or inhibitory control (p > 0.132).<bold>Conclusion: </bold>Myelin loss in NAWM may play a role in the evolution of impaired processing speed and working memory in people with cSVD. Future studies, with a longitudinal design and larger sample sizes, are needed to fully elucidate the role of myelin as a potential biomarker for cognitive function. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13872877
Volume :
80
Issue :
1
Database :
Academic Search Index
Journal :
Journal of Alzheimer's Disease
Publication Type :
Academic Journal
Accession number :
151820892
Full Text :
https://doi.org/10.3233/JAD-201134