HIF-1α promotes ZEB1 expression and EMT in a human bladder cancer lung metastasis animal model.

HIF-1 promotes ZEB1 expression and EMT in a human bladder cancer lung metastasis animal model (B) Wound-healing assay to demonstrate that T24-L cells exhibited higher migration activity than T24-P cells, and T24-L control cells exhibited higher migration activity compared with HIF-1 knockdown T24-L cells. HIF-1 , hypoxia inducible factor-1 ; siRNA, small interfering RNA; T24-L,T24 lung metastasis cells; T24-P, T24 parental cells; NC, negative control. [Extracted from the article]