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Increased systemic exposure of once‐daily tacrolimus in renal transplant recipients on marine omega‐3 fatty acid supplementation.
- Source :
-
Transplant International . Jul2021, Vol. 34 Issue 7, p1322-1324. 3p. - Publication Year :
- 2021
-
Abstract
- In some parts of the world, high intake of marine omega-3 FAs is recommended for the general population and it is likely that RTRs use omega-3 FA supplements without consulting a transplant physician [2]. Doses were kept unchanged between the two sub-study pharmacokinetic investigations. gl The main finding in the present study was that the systemic exposure of once-daily tacrolimus was increased on average by 25% after daily high-dose marine omega-3 FA supplementation. Physicians should be aware that this clinically relevant increase in the systemic exposure of tacrolimus may not necessarily induce a similar increase in trough concentrations [10], which make it difficult to monitor tacrolimus levels following the initiation and discontinuation of marine omega-3 FA supplementation. [Extracted from the article]
Details
- Language :
- English
- ISSN :
- 09340874
- Volume :
- 34
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Transplant International
- Publication Type :
- Academic Journal
- Accession number :
- 151570083
- Full Text :
- https://doi.org/10.1111/tri.13917