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Mechanism of antinociceptive action of syringic acid.
- Source :
-
Journal of Research in Pharmacy . 2021, Vol. 25 Issue 3, p277-286. 10p. - Publication Year :
- 2021
-
Abstract
- Syringic acid presents various biological properties such as antioxidant, anti-inflammatory, anticancer, and other activities. The present experiment aimed to investigate the effect of the oral administration of syringic acid (10, 50, and 100 mg/kg) on its possible nociceptive response using hot-plate and tail-flick assay in the Balb-C mice model. The mice were pre-treated with 5 mg/kg atropine 15 min before, 1mg/kg mecamylamine 20 min before, 1mg/kg ketanserin 30 min before, 1 mg/kg ondansetron 30 min before, 1mg/kg yohimbine 30 min before, 1 mg/kg prazosin 30 min before and 5 mg/kg naloxone 15min before the administration of the Syringic acid. Dose-dependent antinociceptive activity of syringic acid was reported for 50 and 100 mg/kg doses in tail-flick and hot-plate assays, respectively. In further, mecamylamine, yohimbine, and naloxone significantly reversed syringic acid-induced response to thermal stimuli in tail-flick and hot-plate assays, respectively. From the data, it was confirmed that syringic acid presents central antinociceptive effects which may be coordinated by supraspinal/spinal mediated cholinergic, opioidergic, and adrenergic, inflection. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 26306344
- Volume :
- 25
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Research in Pharmacy
- Publication Type :
- Academic Journal
- Accession number :
- 151520126
- Full Text :
- https://doi.org/10.29228/jrp.18