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5‐Aminolaevulinic acid photodynamic therapy amplifies intense inflammatory response in the treatment of acne vulgaris via CXCL8.

Authors :
Zhang, Linglin
Yang, Jiayi
Liu, Xiaojing
Xu, Detian
Shi, Lei
Liu, Jia
Zeng, Qingyu
Wang, Xiuli
Source :
Experimental Dermatology. Jul2021, Vol. 30 Issue 7, p923-931. 9p.
Publication Year :
2021

Abstract

Acne vulgaris is a chronic inflammatory cutaneous disease. 5‐Aminolaevulinic acid photodynamic therapy (ALA‐PDT) is a novel and effective approach for severe acne vulgaris treatment. However, its specific treatment mechanism still remains unclear. In the present study, we investigated the potential mechanism of how ALA‐PDT regulated intense inflammatory response in acne vulgaris. It appeared that ALA‐PDT suppresses proliferation and lipid secretion of primary human sebocytes. Besides, ALA‐PDT could up‐regulate the expression of CXCL8 in vivo and in vitro, amplifying the inflammatory response by recruiting T cells, B cells, neutrophils and macrophages. We also found that ALA‐PDT elevated the expression of CXCL8 via p38 pathway. SB203580, a p38 pathway inhibitor, decreased the expression of CXCL8 in sebocytes after ALA‐PDT. These findings indicate that ALA‐PDT amplifies the intense inflammatory response in the treatment of acne vulgaris via CXCL8. Our data decipher the mechanism of intense inflammatory response after ALA‐PDT for acne vulgaris. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09066705
Volume :
30
Issue :
7
Database :
Academic Search Index
Journal :
Experimental Dermatology
Publication Type :
Academic Journal
Accession number :
151314303
Full Text :
https://doi.org/10.1111/exd.14357