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Split hand phenomenon: An early marker for amyotrophic lateral sclerosis.
- Source :
-
Revista Mexicana de Neurociencia . Jul/Aug2021, Vol. 22 Issue 4, p141-145. 5p. - Publication Year :
- 2021
-
Abstract
- Background: Amyotrophic lateral sclerosis (ALS) is a progressive disease characterized by degeneration of upper and lower motor neurons. Time from symptom onset to confirmed diagnosis has been reported from 8 to 15 months in ALS. Objectives: To describe the frequency of the split hand phenomenon and propose it as an early biomarker for ALS diagnosis. Methods: A retrospective, analytical, descriptive, and single-center observational study was performed. The split hand ratio was determined by dividing distal abductor pollicis brevis/abductor digit minimi compound muscle action potentials; a result < 0.6 was considered present. Results: Fifty-four patients with ALS diagnosis were included in the study. The split hand ratio was identified in 61.5% of patients with definite ALS, in 68.7% with probable ALS, 80% with possible ALS, and in 50% with suspected ALS. The split hand phenomenon was identified in 60% of patients within 12 months of symptom onset. Conclusion: We provide evidence for an additional neurophysiological tool that helps early diagnosis of ALS. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16655044
- Volume :
- 22
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Revista Mexicana de Neurociencia
- Publication Type :
- Academic Journal
- Accession number :
- 151299641
- Full Text :
- https://doi.org/10.24875/RMN.20000135