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Interactions between Caveolin-1 (rs3807992) polymorphism and major dietary patterns on cardio-metabolic risk factors among obese and overweight women.
- Source :
-
BMC Endocrine Disorders . 7/1/2021, Vol. 21 Issue 1, p1-14. 14p. - Publication Year :
- 2021
-
Abstract
- Background: Caveolin-1 (CAV-1) is a cholesterol-dependent essential component located in caveolae. Several studies have been CAV-1 related to cardio-metabolic parameters in animal models, however, there are few studies in humans. Importantly, there is no study has investigated the interaction between CAV-1 rs3807992 gene and dietary patterns (DPs) on cardio-metabolic risk factors. Methods: The current cross-sectional study was conducted on 404 overweight and obese women. Dietary intake was obtained from FFQ with 147 items. The CAV-1 genotype was measured by the PCR-RFLP method. The anthropometric measurements, serum lipid profile, and inflammatory markers were measured by standard protocols. Results: There was a significant interaction between CAV-1 rs3807992 and healthy DP on high-density cholesterol (HDL) (P-interaction = 0.03), TC/HDL (P-interaction = 0.03) and high sensitivity C-reactive protein (hs-CRP) (P-interaction = 0.04); in A-allele carriers, higher following a healthy DP was related to a higher level of HDL and lower TC/HDL and hs-CRP. As well as, the significant interactions were observed between CAV-1 rs3807992 and unhealthy DP in relation to triglyceride (TG) (P-interaction = 0.001), aspartate aminotransferase (AST) (P-interaction = 0.01) and monocyte chemoattractant protein-1(MCP-1) (P-interaction = 0.01); A-allele carriers were more following the unhealthy DP had lower levels of TG, AST and MCP-1. Conclusions: Our study revealed a significant gene-diet interaction between rs3807992 SNPs and DPs in relation to cardio-metabolic risk factors; A-allele carriers might be more sensitive to dietary composition compared to GG homozygotes. Following a healthy DP in A-allele-carriers may be improved their genetic association with cardio-metabolic risk factors. [ABSTRACT FROM AUTHOR]
- Subjects :
- *OBESITY complications
*METABOLIC syndrome risk factors
*PROTEINS
*HDL cholesterol
*C-reactive protein
*TRIGLYCERIDES
*CROSS-sectional method
*ANTHROPOMETRY
*GENETIC polymorphisms
*DIET
*INGESTION
*ALLELES
*QUESTIONNAIRES
*GENOTYPES
*POLYMERASE chain reaction
*INFLAMMATORY mediators
*CHEMOKINES
*LIPIDS
*ASPARTATE aminotransferase
Subjects
Details
- Language :
- English
- ISSN :
- 14726823
- Volume :
- 21
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- BMC Endocrine Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 151207653
- Full Text :
- https://doi.org/10.1186/s12902-021-00800-y