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Synthesis of a potential bendamustine deschloro dimer impurity.
- Source :
-
Journal of Chemical Research . May/Jun2021, Vol. 45 Issue 5/6, p558-561. 4p. - Publication Year :
- 2021
-
Abstract
- Bendamustine deschloro dimer was considered as a potential impurity in bendamustine hydrochloride resulting from the hydrolysis of bendamustine followed by intermolecular esterification. An efficient synthesis of bendamustine deschloro dimer was achieved from 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate involving nine sequential steps including benzyl-protection/deprotection of the amine and carboxylic acid groups, saponification, ring-opening reaction of oxirane as well as Fischer/Steglish esterfication and so on. The target bendamustine deschloro dimer was obtained using a high-performance liquid chromatography in a purity of 95.63%. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17475198
- Volume :
- 45
- Issue :
- 5/6
- Database :
- Academic Search Index
- Journal :
- Journal of Chemical Research
- Publication Type :
- Academic Journal
- Accession number :
- 151191574
- Full Text :
- https://doi.org/10.1177/1747519820945931