Poor responders: what is new in 2021? Are we rising to the challenge?

Introduction. In the field of human assisted reproduction, patients with low ovarian reserve are one of the main challenges for the infertility specialists. This is due to the low number of oocytes obtained after controlled ovarian stimulation cycles. Materials and method. As many studies reveal, the number of oocytes is directly proportional to the rate of blastocysts and the rate of pregnancy. This paper is a review of the literature, with the role of highlighting the news in the field. Results. What can we do for these patients to maximize their chances of pregnancy? Dualstim, luteal phase stimulation, ovarian PRP and growth hormone therapy are just some of the latest options that poor responders seem to benefit from. Conclusions. As we well know, there are no effective methods to increase the ovarian reserve, so the poor responders are always in the center of scientific research, out of a desire to improve the pregnancy rate and the live birth rate. [ABSTRACT FROM AUTHOR]