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Acetazolamide-eluting biodegradable tubular stent prevents pancreaticojejunal anastomotic leakage.
- Source :
-
Journal of Controlled Release . Jul2021, Vol. 335, p650-659. 10p. - Publication Year :
- 2021
-
Abstract
- Postoperative pancreatic fistula at the early stage can lead to auto-digestion, which may delay the recovery of the pancreaticojejunal (PJ) anastomosis. The efficacy and safety of an acetazolamide-eluting biodegradable tubular stent (AZ-BTS) for the prevention of self-digestion and intra-abdominal inflammatory diseases caused by pancreatic juice leakage after PJ anastomosis in a porcine model were investigated. The AZ-BTS was successfully fabricated using a multiple dip-coating process. Then, the drug amount and release profile were analyzed. The therapeutic effects of AZ were examined in vitro using two kinds of pancreatic cancer cell lines, AsPC-1 and PANC-1. The efficacy of AZ-BTS was assessed in a porcine PJ leakage model, with animals were each assigned to a leakage group, a BTS group and an AZ-BTS group. The overall mortality rates in these three groups were 44.4%, 16.6%, and 0%, respectively. Mean α-amylase concentrations were significantly higher in the leakage and BTS groups than in the AZ-BTS group on day 2–5 (p < 0.05 each all). The luminal diameters and areas of the pancreatic duct were significantly larger in the leakage group than in the BTS and AZ-BTS groups (p < 0.05 each all). These findings indicate that AZ-BTS can significantly suppress intra-abdominal inflammatory diseases caused by pancreatic juice leakage and also prevent late stricture formation at the PJ anastomotic site in a porcine model. [Display omitted] • AZ-BTS effectively suppresses self-digestion caused by pancreatic juice leakage. • BTS with or without AZ has inhibitory effect of anastomotic stricture formation. • AZ-BTS was fabricated by a multiple dip-coating technique with reliable release. • The releases AZ, targets carbonic anhydrase, protects tisssues from pancreatic juice. • Animal model induced a reproducible incidence of anastomotic leakage and symptoms. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01683659
- Volume :
- 335
- Database :
- Academic Search Index
- Journal :
- Journal of Controlled Release
- Publication Type :
- Academic Journal
- Accession number :
- 151154106
- Full Text :
- https://doi.org/10.1016/j.jconrel.2021.06.010