Cu(II)-based coordination polymers: protective effect on suppurative lymphadenitis by regulating miR-155 and miR-34a expression in the lymph node cells.

Using bis(tridentate)polypyridyl ligands, two new 2 D (two-dimensional) coordination polymers (CPs), {Cu2(tpbn)(2,6-NDC)2}n (1) and {[Cu2(tphn)(2,6-NDC)2]·4H2O}n (2), where tpbn = N,N′,N″,N‴-tetrakis(2-pyridylmethyl)-1,4-diaminobutane, tphn = N,N′,N″,N‴-tetrakis(2-pyridylmethyl)-1,6-diaminohexane, and 2,6-H2NDC = 2,6-naphthalenedicarboxylic acid, were obtained in high yield in a mixed solvent system. 1 and 2 were characterized via single-crystal X-ray diffraction, powder X-ray diffraction, FT-IR spectroscopy and TG analysis. Real-time transcription-polymerase chain reaction (RT-PCR) was conducted to evaluate the relative activity of the miR-155 and miR-34a in the lymph node cells during bacterial infection. After treatment with 1 or 2, the quantity of inflammatory cytokines produced by the lymph node cells was evaluated by enzyme linked immunosorbent assay (ELISA) detection equipment. [ABSTRACT FROM AUTHOR]