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IL-3 inhibits rat osteoclast differentiation induced by TNF-α and other pro-osteoclastogenic cytokines.
- Source :
-
Journal of Biosciences . 6/26/2021, Vol. 46 Issue 3, p1-12. 12p. - Publication Year :
- 2021
-
Abstract
- IL-3, a haematopoiesis regulatory factor, has previously been shown to inhibit both mouse and human osteoclast differentiation and bone resorption. Here, the role of rat IL-3 on rat osteoclast differentiation was evaluated to address whether the inhibitory action of IL-3 on osteoclastogenesis is conserved in various species. It was observed that IL-3 inhibited rat osteoclast differentiation induced by both TNF-α and receptor activator of NF-κB ligand (RANKL). TNF-α is known to induce bone loss in postmenopausal osteoporotic women and it also synergise with many pro-osteoclastogenic cytokines to cause huge pathological bone loss. Importantly, it was found that rat IL-3 inhibits the synergistic action of TNF-α with RANKL and IL-1β, TGF-β1 and TGF-β3. IL-3 downregulates the TNF-α-induced nuclear translocation of NF-κB-p65 and c-fos without affecting c-jun. Interestingly, we observed that IL-3 also inhibits osteoclast differentiation in vivo in rats induced by TNF-α. All these results suggest that inhibitory action of IL-3 on osteoclastogenesis is conserved in various species including mice, rats and humans. Thus, our results clearly indicate that IL-3 has therapeutic potential to treat pathological bone loss in important skeletal diseases. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02505991
- Volume :
- 46
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Biosciences
- Publication Type :
- Academic Journal
- Accession number :
- 151081115
- Full Text :
- https://doi.org/10.1007/s12038-021-00181-3