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Intracoronary Thrombolysis in Patients With ST-Segment Elevation Myocardial Infarction: A Meta-Analysis of Randomized Controlled Trials.
- Source :
-
Angiology . Aug2021, Vol. 72 Issue 7, p679-686. 8p. - Publication Year :
- 2021
-
Abstract
- Background: The effects of intracoronary (IC) thrombolysis therapy in patients with ST-segment elevation myocardial infarction (STEMI) receiving primary percutaneous coronary intervention (PPCI) remain unclear. Methods: The meta-analysis was conducted according to the PRISMA statement. All relevant studies were identified by searching the PubMed, EMBASE, Cochrane Library, and Web of Science, with no time or language limitation. The pooled risk ratio (RR) and weighted mean difference (WMD) with a 95% CI were calculated. Results: Nine randomized controlled trials involving a total of 1341 patients were included. Compared with the control group, IC thrombolysis in patients with STEMI could reduce the incidence of major adverse cardiac events (MACE; RR 0.632, 95% CI, 0.474-0.843, P =.002) and improve left ventricular ejection fraction (RR 0.343, 95% CI, 0.178-0.509, P <.001) and myocardial microcirculation. However, there was no difference noted in the mortality (RR 0.759, 95% CI, 0.347-1.661, P =.490). The incidence rate of major bleeding and minor bleeding was comparable between the 2 groups. Conclusions: Intracoronary thrombolysis was associated with improved MACE and myocardial microcirculation in patients with STEMI having PPCI, though it failed to improve mortality. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ONLINE information services
*RELATIVE medical risk
*CARDIOVASCULAR diseases risk factors
*PERCUTANEOUS coronary intervention
*META-analysis
*MEDICAL information storage & retrieval systems
*INFORMATION storage & retrieval systems
*MEDICAL databases
*CONFIDENCE intervals
*VENTRICULAR ejection fraction
*SYSTEMATIC reviews
*MYOCARDIAL infarction
*THROMBOLYTIC therapy
*MICROCIRCULATION
*SURGICAL complications
*TREATMENT effectiveness
*RISK assessment
*ELECTROCARDIOGRAPHY
*DESCRIPTIVE statistics
*MEDLINE
*HEMORRHAGE
*EVALUATION
SURGICAL complication risk factors
MYOCARDIAL infarction-related mortality
Subjects
Details
- Language :
- English
- ISSN :
- 00033197
- Volume :
- 72
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Angiology
- Publication Type :
- Academic Journal
- Accession number :
- 151079581
- Full Text :
- https://doi.org/10.1177/0003319721995039