Ateroskleróza ve světle prevence, diagnostiky a léčby.

Brief history of atherosclerosis discovery and its risk factors are presented in this summarizing article. Contemporary view on the atherosclerosis pathophysiology proceeds from the EAS consensus, in which is LDL‑cholesterol considered as the main causal risk factor for atherosclerosis and atherosclerosis as a very frequent disease occuring in middle aged 71 % male and 43 % female. Atherosclerosis prevention and treatment are based on the global cardiovascular risk assessment and on the influence of all present risk factors, esp. on the intensive reduction of LDL‑cholesterol as a primary target. If is statin mono‑ therapy or combination with ezetimibe not successful, PCSK9 inhibitors are recommended to add. Except of a big evidence from experimental, clinical and epidemiological studies about the lipid modifying therapy profit exists, some disputes to that therapy including the „cholesterol hypothesis“ of atherosclerosis are appearing. [ABSTRACT FROM AUTHOR]