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Evaluation of left ventricular myocardial mechanics in patients with normally functioning bicuspid aortic valves: A systematic review and meta‐analysis.
- Source :
-
Echocardiography . Jun2021, Vol. 38 Issue 6, p834-843. 10p. - Publication Year :
- 2021
-
Abstract
- Background: Studies have found conflicting results concerning the left ventricular (LV) myocardial deformation properties in patients with normally functioning bicuspid aortic valves (BAVs). Whether the remodeling process of LV occurs independently in patients with BAV is a matter of debate. Method: We searched PubMed, Embase, Cochrane library, and Web of Science for cohort studies aiming to assess LV function in adults with isolated BAV compared with tricuspid aortic valve (TAV) controls. Standard mean difference (SMD) was calculated from random‐effects meta‐analyses. Results: Eight cohort studies were included. There were significantly lower global longitudinal strain (GLS), global radial strain (GRS), global circumferential strain (GCS) in BAV than in TAV controls (GLS: SMD = 0.64, 95% CI: 0.35 to 0.92, P <.0001; GRS: SMD = −0.71, 95% CI: −1.09 to −0.32, P =.0003; GCS: SMD = 0.70, 95% CI: 0.41 to 0.98, P <.00001) and significantly higher left atrial volume index (LAVI) and E/e' in BAV than in TAV controls (LAVI: SMD = 0.50, 95% Cl: 0.12 to 0.88, P =.01; E/e': SMD = 0.54, 95% CI: 0.30 to 0.77, P <.00001). There was significantly higher Left ventricular mass index(LVMI) in BAV than in TAV controls (SMD = 0.51, 95% CI: 0.24 to 0.79, P =.0003). Left ventricular ejection fraction (LVEF) was not significantly different between BAV patients and TAV controls (SMD = 0.05, 95% CI: −0.16 to 0.26, P =.63). Conclusion: The impairment of LV myocardial mechanics, including LV systolic, diastolic dysfunction and LV hypertrophy, is present in patients with normally functioning BAV. This might support the hypothesis that BAV is not only a valvular disease but also a myocardial disease. [ABSTRACT FROM AUTHOR]
- Subjects :
- *LEFT heart ventricle
*ONLINE information services
*MYOCARDIUM
*META-analysis
*MEDICAL information storage & retrieval systems
*MEDICAL databases
*INFORMATION storage & retrieval systems
*CONFIDENCE intervals
*VENTRICULAR ejection fraction
*LEFT ventricular hypertrophy
*SYSTEMATIC reviews
*DESCRIPTIVE statistics
*HEART ventricle diseases
*MEDLINE
*AORTIC valve
Subjects
Details
- Language :
- English
- ISSN :
- 07422822
- Volume :
- 38
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Echocardiography
- Publication Type :
- Academic Journal
- Accession number :
- 150943755
- Full Text :
- https://doi.org/10.1111/echo.15042