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Evaluation of COVID-19 antigen fluorescence immunoassay test for rapid detection of SARS-CoV-2.

Authors :
Kiro, Vandana
Gupta, Ankesh
Singh, Parul
Sharad, Neha
Khurana, Surbhi
S, Prakash
Dar, Lalit
Malhotra, Rajesh
Wig, Naveet
Kumar, Arvind
Trikha, Anjan
Mathur, Purva
Source :
Journal of Global Infectious Diseases. Apr-Jun2021, Vol. 13 Issue 2, p91-93. 3p.
Publication Year :
2021

Abstract

Introduction: Tests detecting SARS-CoV-2-specific antigen have recently been developed, and many of them are now commercially available. However, the real-world performance of these assays is uncertain; therefore, their validation is important. In this study, we have evaluated the performance of STANDARD F COVID-19 antigen fluorescence immunoassay (FIA) kit. Methods: Nasopharyngeal samples collected from patients were subjected to the test as per manufacturer's instructions. The performance of the kit was compared with the gold standard real-time polymerase chain reaction. Results: A total of 354 patients were tested with STANDARD F COVID-19 antigen FIA test kit. The overall sensitivity, specificity, positive predictive value, and negative predictive value of this test were found to be 38%, 99%, 96.2%, and 72%, respectively, with a diagnostic accuracy of 75.7%. Conclusion: STANDARD F COVID-19 antigen FIA showed high specificity and positive predictive value but low sensitivity and negative predictive value. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0974777X
Volume :
13
Issue :
2
Database :
Academic Search Index
Journal :
Journal of Global Infectious Diseases
Publication Type :
Academic Journal
Accession number :
150891487
Full Text :
https://doi.org/10.4103/jgid.jgid_316_20